Failure of Current Laboratory Protocols to Detect Lot-to-Lot Reagent Differences: Findings and Possible Solutions

Failure of current laboratory protocols to detect lot-to-lot reagent differences: findings and possible solutions.

BACKGROUND Maintaining consistency of results over time is a challenge in laboratory medicine. Lot-to-lot reagent changes are a major threat to consistency of results. METHODS For the period October 2007 through July 2012, we reviewed lot validation data for each new lot of insulin-like growth factor 1 (IGF-1) reagents (Siemens Healthcare Diagnostics) at Mayo Clinic, Rochester, MN, and the Un...

More on lot-to-lot changes.

How to Use MRP in Continuous Production Industries When Order Type is Lot for Lot

The Materials Requirements Planning (MRP) method that is applied in production planning and management has some weaknesses. One of its weaknesses is that the time in MRP method is discrete, and is considered as time period. Hence we are not able to order our requirements at irregular time moments or periods. In this paper, a new form of MRP is introduced that is named Continuous Materials Requi...

From Parking Lot to Paradise.

Lot-to-lot variation in anti-hepatitis C signal-to-cutoff ratio.

Lot-to-Lot Variation in Anti-Hepatitis C Signal-to-Cutoff Ratio, D. Robert Dufour (Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, and Department of Pathology, The George Washington University Medical Center, Washington, DC; address for correspondence: Pathology and Laboratory Medicine Service-113, Veterans Affairs Medical Center, 50 Irving St. NW, Washington DC 2042...